Quantum-inspired Machine Learning on high-energy physics data

Tensor Networks, a numerical tool originally designed for simulating quantum many-body systems, have recently been applied to solve Machine Learning problems. Exploiting a tree tensor network, we apply a quantum-inspired machine learning technique to a very important and challenging big data problem in high energy physics: the analysis and classification of data produced by the Large Hadron Collider at CERN. In particular, we present how to effectively classify so-called b-jets, jets originating from b-quarks from proton-proton collisions in the LHCb experiment, and how to interpret the classification results. We exploit the Tensor Network approach to select important features and adapt the network geometry based on information acquired in the learning process. Finally, we show how to adapt the tree tensor network to achieve optimal precision or fast response in time without the need of repeating the learning process. These results pave the way to the implementation of high-frequency real-time applications, a key ingredient needed among others for current and future LHCb event classification able to trigger events at the tens of MHz scale.Comment: 13 pages, 4 figure

GIS-Based Geopedological Approach for Assessing Land Suitability for Chestnut (Castanea sativa Mill.) Groves for Fruit Production

The identification of mountainous areas suitable for chestnut stands for fruit production (CSFP) is raising increasing interest among researchers. This work aimed to (i) identify the areas suitable for CSFP shown in a land suitability map easy to read by land planners, and (ii) propose a remote-sensing-based methodology able to identify the lands currently under cultivation for CSFP. This study was conducted using the QGIS software for the Municipality of Castel del Rio, Emilia-Romagna Region, Italy. To obtain the land suitability map, topographic, lithological, and pedological data were acquired, and the areas located between 200 and 1000 m of altitude, with north exposition, a slope < 20°, sandstone-based lithology, and soils with dystric features were selected. The currently cultivated areas for CSFP were identified through remote-sensing images of the early spring period, which were delineated and georeferenced. The findings showed that only 10% of the whole study site area can be considered suitable for CSFP. Further, most of the currently cultivated CSFP (59%) are in non-suitable areas characterised by high slope gradients. The methodology applied in this study can easily provide detailed information about the suitable areas for CSFP and the areas currently cultivated with chestnut, thus allowing accurate land-use planning and land conservation

HST Grism Observations of a Gravitationally Lensed Redshift 10 Galaxy

We present deep spectroscopic observations of a Lyman-break galaxy candidate (hereafter MACS1149-JD) at $z\sim9.5$ with the $\textit{Hubble}$ Space Telescope ($\textit{HST}$) WFC3/IR grisms. The grism observations were taken at 4 distinct position angles, totaling 34 orbits with the G141 grism, although only 19 of the orbits are relatively uncontaminated along the trace of MACS1149-JD. We fit a 3-parameter ($z$, F160W mag, and Ly$\alpha$ equivalent width) Lyman-break galaxy template to the three least contaminated grism position angles using an MCMC approach. The grism data alone are best fit with a redshift of $z_{\mathrm{grism}}=9.53^{+0.39}_{-0.60}$ ($68\%$ confidence), in good agreement with our photometric estimate of $z_{\mathrm{phot}}=9.51^{+0.06}_{-0.12}$ ($68\%$ confidence). Our analysis rules out Lyman-alpha emission from MACS1149-JD above a $3\sigma$ equivalent width of 21 \AA{}, consistent with a highly neutral IGM. We explore a scenario where the red $\textit{Spitzer}$/IRAC $[3.6] - [4.5]$ color of the galaxy previously pointed out in the literature is due to strong rest-frame optical emission lines from a very young stellar population rather than a 4000 \AA{} break. We find that while this can provide an explanation for the observed IRAC color, it requires a lower redshift ($z\lesssim9.1$), which is less preferred by the $\textit{HST}$ imaging data. The grism data are consistent with both scenarios, indicating that the red IRAC color can still be explained by a 4000 \AA{} break, characteristic of a relatively evolved stellar population. In this interpretation, the photometry indicate that a $340^{+29}_{-35}$ Myr stellar population is already present in this galaxy only $\sim500~\mathrm{Myr}$ after the Big Bang.Comment: Accepted to ApJ. This is the accepted versio

The puzzling properties of the MACS1149-JD1 galaxy at z=9.11

We analyze new JWST NIRCam and NIRSpec data on the redshift 9.11 galaxy MACS1149-JD1. Our NIRCam imaging data reveal that JD1 comprises three spatially distinct components. Our spectroscopic data indicate that JD1 appears dust-free but is already enriched, $12 + \log {\rm (O/H) } = 7.90^{+0.04}_{-0.05}$. We also find that the Carbon and Neon abundances in JD1 are below the solar abundance ratio. Particularly the Carbon under-abundance is suggestive of recent star formation where Type~II supernovae have already enriched the ISM in Oxygen but intermediate mass stars have not yet enriched the ISM in Carbon. A recent burst of star formation is also revealed by the star formation history derived from NIRCam photometry. Our data do not reveal the presence of a significant amount of old populations, resulting in a factor of $\sim7\times$ smaller stellar mass than previous estimates. Thus, our data support the view that JD1 is a young galaxy.Comment: Accepted for publicatio

Case report of Usutu virus infection in an immunocompromised patient in Italy, 2022

Usutu virus (USUV) is an arthropod-borne flavivirus emerged in Africa in 1950s and in Eruope in 1990s causing a massive number of birds' deaths. The role of USUV as human pathogen has been only recently hypothesized and cases of USUV infection in humans remain limited and often related to immunocompromised subjects. Herein, we report a case of USUV meningoencephalitis infection in an immunocompromised patient with no history of previous flavivirus infection. The infection due to USUV evolved rapidly since hospital admission thus resulting fatal in few days after symptoms onset and, although not proven, a suspected bacteria co-infection has been hypothesized. Based on these findings, we suggested that when USUV meningoencephalitis is suspected in countries endemic, careful attention should be applied to neurological syndromes during summer months especially among immunocompromised patients

Anti-TNF-α drugs differently affect the TNFa-sTNFR system and monocyte subsets in patients with psoriasis

TNF-a has a central role in the development and maintenance of psoriatic plaques, and its serum levels correlate with disease activity. Anti-TNF-a drugs are, however, ineffective in a relevant percentage of patients for reasons that are currently unknown. To understand whether the response to anti-TNF-a drugs is influenced by the production of anti-drug antibodies or by the modulation of the TNFa-TNFa receptor system, and to identify changes in monocyte phenotype and activity, we analysed 119 psoriatic patients who either responded or did not respond to different anti-TNF-a therapies (adalimumab, etanercept or infliximab), and measured plasma levels of TNF-a, TNF-a soluble receptors, drug and anti-drug antibodies. Moreover, we analyzed the production of TNF-a and TNF-α soluble receptors by peripheral blood mononuclear cells (PBMCs), and characterized different monocyte populations. We found that: i) the drug levels varied between responders and non-responders; ii) anti-infliximab antibodies were present in 15% of infliximab-treated patients, while anti-etanercept or anti-adalimumab antibodies were never detected; iii) plasma TNF-a levels were higher in patients treated with etanercept compared to patients treated with adalimumab or infliximab; iv) PBMCs from patients responding to adalimumab and etanercept produced more TNF-a and sTNFRII in vitro than patients responding to infliximab; v) PBMCs from patients not responding to infliximab produce higher levels of TNF-a and sTNFRII than patients responding to infliximab; vi) anti- TNF-a drugs significantly altered monocyte subsets. A complex remodelling of the TNFa-TNFa receptor system thus takes place in patients treated with anti-TNF-α drugs, that involves either the production of anti-drug antibodies or the modulation of monocyte phenotype or inflammatory activity

Primary, secondary and compensated male biochemical hypogonadism in people living with HIV (PLWH): relevance of sex hormone-binding globulin (SHBG) measurement and comparison between liquid chromatography-tandem mass spectrometry (LC-MS/MS) and chemiluminescent immunoassay for sex steroids assay

Background: Data about classification of hypogonadism and estrogen deficiency in male people living with HIV (PLWH) are scanty. Aim: To investigate the prevalence and characterization of biochemical hypogonadism and relative estrogen deficiency in male PLWH aged < 50 comparing liquid chromatography-tandem mass spectrometry (LC-MS/MS) with chemiluminescent immunoassay (CI), and combining gonadotropin, sex hormone-binding globulin (SHBG) and serum estradiol (E2) measurements. Methods: Prospective, cross-sectional, observational study. Serum total testosterone (TT), E2, gonadotropins, SHBG were measured by CI. TT and E2 were also assessed by LC-MS/MS. Free testosterone (cFT) was calculated by Vermeulen equation. Results: A total of 316 PLWH (45.3 ± 5.3 years) were enrolled. TT and cFT by LC-MS/MS were lower compared to CI (p < 0.0001). The prevalence of biochemical hypogonadism was higher with LC-MS/MS than CI, both for TT (5.1% vs 3.2%, p < 0.0001) or cFT (9.5% vs 7%, p < 0.0001). The prevalence of hypogonadism (overt + compensated) was 17.1% for cFT using LC-MS/MS. Secondary form of hypogonadism was more prevalent than primary. The prevalence of relative estrogen deficiency was of 30.0% among hypogonadal patients and 15.5% among eugonadal. Conclusions: The prevalence of male hypogonadism results underestimated by CI compared to LC-MS/MS in PLWH, both for TT and cFT. SHBG and gonadotropins are essential for detecting T deficiency.Background: Data about classification of hypogonadism and estrogen deficiency in male people living with HIV (PLWH) are scanty. Aim: To investigate the prevalence and characterization of biochemical hypogonadism and relative estrogen deficiency in male PLWH aged < 50 comparing liquid chromatography-tandem mass spectrometry (LC-MS/MS) with chemiluminescent immunoassay (CI), and combining gonadotropin, sex hormone-binding globulin (SHBG) and serum estradiol (E2) measurements. Methods: Prospective, cross-sectional, observational study. Serum total testosterone (TT), E2, gonadotropins, SHBG were measured by CI. TT and E2 were also assessed by LC-MS/MS. Free testosterone (cFT) was calculated by Vermeulen equation. Results: A total of 316 PLWH (45.3 ± 5.3 years) were enrolled. TT and cFT by LC-MS/MS were lower compared to CI (p < 0.0001). The prevalence of biochemical hypogonadism was higher with LC-MS/MS than CI, both for TT (5.1% vs 3.2%, p < 0.0001) or cFT (9.5% vs 7%, p < 0.0001). The prevalence of hypogonadism (overt + compensated) was 17.1% for cFT using LC-MS/MS. Secondary form of hypogonadism was more prevalent than primary. The prevalence of relative estrogen deficiency was of 30.0% among hypogonadal patients and 15.5% among eugonadal. Conclusions: The prevalence of male hypogonadism results underestimated by CI compared to LC-MS/MS in PLWH, both for TT and cFT. SHBG and gonadotropins are essential for detecting T deficiency

Innate immunity changes in soccer players after whole-body cryotherapy

Whole-body cryotherapy (WBC) consists of short exposure (up to 2-3 min) to dry air at cryogenic temperatures (up to -190 degrees C) and has recently been applied for muscle recovery after injury to reduce the inflammation process. We aimed to determine the impact of cryotherapy on immunological, hormonal, and metabolic responses in non-professional soccer players (NPSPs). Nine male NPSPs (age: 20 +/- 2 years) who trained regularly over 5 consecutive days, immediately before and after each training session, were subjected to WBC treatment (WBC-t). Blood samples were collected for the evaluation of fifty analytes including hematologic parameters, serum chemistry, and hormone profiles. Monocytes phenotyping (Mo) was performed and plasmatic markers, usually increased during inflammation [CCL2, IL-18, free mitochondrial (mt)DNA] or with anti-inflammatory effects (IL2RA, IL1RN), were quantified. After WBC-t, we observed reduced levels of ferritin, mean corpuscular hemoglobin, mean platelet volume, testosterone, and estradiol, which however remain within the normal ranges. The percentage of the total, intermediates and non-classical Mo increased, while classical Mo decreased. CXCR4 expression decreased in each Mo subset. Plasma IL18 and IL2RA levels decreased, while IL1RN only exhibited a tendency to decrease and CCL2 showed a tendency to increase. Circulating mtDNA levels were not altered following WBC-t. The differences observed in monocyte subsets after WBC-t may be attributable to their redistribution into the surrounding tissue. Moreover, the decrease of CXCR4 in Mo subpopulations could be coherent with their differentiation process. Thus, WBC through yet unknown mechanisms could promote their differentiation having a role in tissue repair

Detailed characterization of SARS-CoV-2-specific T and B cells after infection or heterologous vaccination

: The formation of a robust long-term antigen (Ag)-specific memory, both humoral and cell-mediated, is created following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination. Here, by using polychromatic flow cytometry and complex data analyses, we deeply investigated the magnitude, phenotype, and functionality of SARS-CoV-2-specific immune memory in two groups of healthy subjects after heterologous vaccination compared to a group of subjects who recovered from SARS-CoV-2 infection. We find that coronavirus disease 2019 (COVID-19) recovered patients show different long-term immunological profiles compared to those of donors who had been vaccinated with three doses. Vaccinated individuals display a skewed T helper (Th)1 Ag-specific T cell polarization and a higher percentage of Ag-specific and activated memory B cells expressing immunoglobulin (Ig)G compared to those of patients who recovered from severe COVID-19. Different polyfunctional properties characterize the two groups: recovered individuals show higher percentages of CD4+ T cells producing one or two cytokines simultaneously, while the vaccinated are distinguished by highly polyfunctional populations able to release four molecules, namely, CD107a, interferon (IFN)-γ, tumor necrosis factor (TNF), and interleukin (IL)-2. These data suggest that functional and phenotypic properties of SARS-CoV-2 adaptive immunity differ in recovered COVID-19 individuals and vaccinated ones